The announcement comes weeks before the 38-year-old crossover star takes on Kiwi fighter Mark Hunt in his return to MMA at July's UFC 200.
Wrestling legend Goldberg has also been announced as a bonus feature for those who pre-order WWE 2K17.
Lesnar remains under contract with WWE and is scheduled to be part of its SummerSlam pay-per-view in August. The company agreed to a "one-off opportunity" for Lesnar to compete in UFC.
The 38-year-old American has previously appeared on the covers of 2002's WWE SmackDown: Shut Your Mouth and 2003's WWE SmackDown: Here Comes the Pain.
Hunt has issued Lesnar with a stern warning over their upcoming face-off, saying: "Don't confuse wrestling with real fighting. I'm going to give it to him.
"He thinks this is a game where he can come back and forth. I will send this pretender back so he can play house with the other part-timers. This realm is for the real fighters, not these damn pretenders."
